Review on Nano-Emulsion Drug Delivery System and Formulation, Evaluation and Their Pharmaceutical Applications
DOI:
https://doi.org/10.55938/ijhcn.v2i1.43Keywords:
Nano-emulsion, Types of Nano- emulsion, Surfactants, Novel drug delivery, Pharmaceutical ApplicationAbstract
Nano-emulsion drug delivery system such as develop to eliminate the limitations with traditional drug administration system. This review provided a good overview of the recent advances in the Nano-emulsion drug delivery system. These are nano-sized submicron emulsions developed to enhanced the circulates of active pharmaceutical ingredients to targeted site. Nano-emulsion is a homogeneous mixture of lipid and aqueous phase and stabilization is obtained through the use of an effective substance such as emulsifying agents. The droplet size has been range between the 50-500 nm. The size and shape of the substance distributed throughout the usual process differentiates of emulsion, micro-emulsion, and nano-emulsion. Nano-emulsion gives a novel dosage form for less water solubility drugs and increases pharmacological activity of drugs. Nano-emulsion is used in the future cosmetic industry, diagnostic testing, drug treatment, and biotechnology. This analysis aims to include brief information on the nano-emulsion, advantages, disadvantages, limitations of nano-emulsion, types of nano-emulsion, components of formulations, surface active agents (Surfactant), preparation methods, characterization methods with strong attention of different pharmaceutical applications of nano-emulsion in a different area such as cancer and tumors therapy, targeted drug delivery, mucosal vaccine, trans-dermal drug delivery system.
References
Anton N, Benoit JP, Saulnier P. Design and production of nanoparticles formulated from nano-emulsion templates-a review. J Control Release. 2008;128:185–199.
Sharma SN, Jain NK (1985) A text book of professional pharmacy. Vallabh Prakashan, 1st edn, p 201.
Acharya, D. P., and Hartley, P. G. (2012). Progress in microemulsion characterization. Curr. Opin. Colloid Interface Sci. 17, 274–280. DOI: https://doi.org/10.1016/j.cocis.2012.07.002
Anton, N., Benoit, J.-P., and Saulnier, P. (2008). Design and production of nanoparticles formulated from nano-emulsion templates—a review. J. Control. Release 128, 185–199. DOI: https://doi.org/10.1016/j.jconrel.2008.02.007
Bai, L., Huan, S., Gu, J., and McClements, D. J. (2016). Fabrication of oil-in-water nanoemulsions by dual-channel microfluidization using natural emulsifiers: Saponins, phospholipids, proteins, and polysaccharides. Food Hydrocoll. 61, 703–711. DOI: https://doi.org/10.1016/j.foodhyd.2016.06.035
A. A., Desai, N.,Dixit, R., and Nagarsenker, M. (2010). Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine 5, 1595–1616. DOI: https://doi.org/10.2217/nnm.10.126
Thiagarajan P. and Ravi Theaj P.U. Nanoemulsions for drug delivery through different routes. Research in Biotechnology. 2011; 2 (3):01-13.
Delmas T, Piraux H, Couffin AC, Texier I, Vinet FO, Poulin P, et al., How To Prepare and Stabilize Very Small Nanoemulsions. Langmuir. 2011; 27(5):1683-1692. DOI: https://doi.org/10.1021/la104221q
Baboota S, Shakeel F, Ahuja A, Javed Ali, Shafiq S. Design, Development and Evaluation of Novel Nanoemulsion Formulations for Transdermal Potential of Celecoxib. Acta Pharm. 2007; 57:315-332. DOI: https://doi.org/10.2478/v10007-007-0025-5
Dey S., Jha S.K., Malakar J., Gangopadhyay A. Improvement of Bioavailability of Poorly Soluble Drugs through Self Emulsifying Drug Delivery System. Journal of PharmaSciTech. 2012; 1(2):6-11.
Mangale M.R., Pathak S.S., Mene H.R., More B.A. Nanoemulsion: As Pharmaceutical Overview. Int. J. Pharm. Sci. Rev. Res. 2015; 33(1):244-252.
Kumar S. H. and Singh V. Nanoemulsification - A Novel Targeted Drug Delivery Tool. Journal of Drug Delivery and Therapeutics. 2012; 2(4):40- 45. DOI: https://doi.org/10.22270/jddt.v2i4.185
Sharma N, Bansal M, Visht S, Sharma PK, Kulkarni GT. Nanoemulsion: A New Concept of Delivery System. Chronicles of Young Scientists. 2010; 1(2):2-6.
Thakur N, Garg G, Sharma P.K. and Kumar N. Nanoemulsions: A Review on Various Pharmaceutical Application. Global Journal of Pharmacology. 2012; 6(3):222-225.
Mahajan H.S., Mahajan M.S., Nerkar P.P., and Agrawal A. Nanoemulsion-based intranasal drug delivery system of Saquinavir mesylate for brain targeting. Drug Deliv. 2014; 21(2):148-154. DOI: https://doi.org/10.3109/10717544.2013.838014
Reddy B AK, Debnath S, Babu M.N. Nanoemulsion A Novel Approach For Lipophilic Drugs -A Review. Asian J. Pharm. Res. 2013; 3(2):84-92.
Mishra R.K., Soni G.C., Mishra R. Nanoemulsion: A Novel Drug Delivery Tool. International Journal of Pharma Research and Review. 2014; 3(7):32-43.
Khasia H.V and Khasia V.D. A Review on Self Emulsifying Drug Delivery System. International Journal of Pharmaceutical and Chemical Sciences.2012; 1(1):353-359.
Amrutkar C., Salunkhe K., Chaudhari S. Study on Self Nano Emulsifying Drug Delivery System of Poorly Water Soluble Drug Rosuvastatin Calcium. WJPR. 2014; 3(4):2137-2151.
Sessa M., Luisa M. B., Ferrari G., Servillo L., Castaldo D., D’Onofrio N., et al., Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems. Food Chemistry. 2014; 147:42-50. DOI: https://doi.org/10.1016/j.foodchem.2013.09.088
Shah P, Bhalodia D, Shelat P, Nanoemulsion: A Pharmaceutical Review. Sys Rev Pharm. 2010; 1(1):24. DOI: https://doi.org/10.4103/0975-8453.59509
Debnath S., Satayanarayana and Gampa V. K. Nanoemulsion-A Method to Improve the Solubility of Lipophilic Drugs. PharmanestAn International Journal of Advances in Pharmaceutical Sciences. 2011; 2(3):72-83.
Sharma1 N., Bansa M., Visht S., Sharma PK, Kulkarni GT. Nanoemulsion: A new concept of delivery system. Chronicles of Young Scientists. 2010; 1(2):2-6.
Dhas A., Deshmulkh G., Andhale V., Patil P., Pansare S., Mundke S. Review on Nanoemulsion: A Novel Drug Delivery System.Ejbps. 2016; 3(4):156-166.
Garg J., Kumar P. Emerging Trends in Nanoemulsion Design and Therapeutics: A Review. AJPSCR. 2014; 2(3):1-16.
Selvam R.P., Kulkarni P.K. Design and Evaluation of Self Nanoemulsifying Systems for Poorly Water Soluble HIV Drug. Journal of PharmaSciTech. 2014; 4(1):23-28.
Vanitasagar S. and Subhashini N.J.P. Novel Self-Nanoemulsion Drug Delivery System of Fenofibrate with Improved BioAvailability. Int J Pharm Bio Sci. 2013; 4(2):511-521.
Azeem A., Rizwan M., Ahmad F. J., Iqbal Z., Khar R. K., Aqil M., et al., Nanoemulsion Components Screening and Selection: a Technical Note. AAPS PharmSciTech. 2009; 10(1):69-76. DOI: https://doi.org/10.1208/s12249-008-9178-x
Gautam S., Kumar S., Self Nanoemulsifying Drug Delivery System-A Novalapproach for Improving Bioavailability. Journal of Drug Delivery and Therapeutics. 2014; 4(6):33- 38. DOI: https://doi.org/10.22270/jddt.v4i6.989
Soni G.C., Prajapati S.K., Chaudhr N. Self Nanoemulsion: Advance Form of Drug Delivery System. Wjpps. 2014; 3(10):410- 436.
Zanchetta B., Chaud M.V., Maria H., Santana A. Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development. J AdvChem Eng. 2015; 5:130:1-7. DOI: https://doi.org/10.4172/2090-4568.1000130
Kaur G., Chandel P., Harikumar S.L. Formulation Development of Self Nanoemulsifying Drug Delivery System (SNEDDS) of Celecoxib for Improvement of Oral Bioavailability. Pharmacophore. 2013; 4(4):120-133.
Bangia J. K. and Om H., Nanoemulsions: A Versatile Drug Delivery Tool. IJPSR. 2015; 6(4):1363-1372.
Gadhave A.D. Nanoemulsions: Formation, Stability and Applications. International Journal for Research in Science and Advanced Technologies. 2014; 2(3):038- 043.
Wooster T.J., Matt G., Peerasak S., Impact of Oil Type on Nanoemulsion Formation and Ostwald Ripening Stability. Langmuir. 2008; 24:12758-12765. DOI: https://doi.org/10.1021/la801685v
Makadia H.A., Bhatt A.Y., Parmar R.B., Paun J.S., Tank H.M. Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects. Asian J. Pharm. Res. 2013; 3(1):21-27.
Meena A.K., Sharma K., Kandaswamy M., Rajagopal S., Mullangi R. Formulation development of an albendazole selfemulsifying drug delivery system (SEDDS) with enhanced systemic exposure. Acta Pharm. 2012; 62:563-580. DOI: https://doi.org/10.2478/v10007-012-0031-0
Singh Y.K., Chandra A., Dashrath, Tyagi L. Review article on Nanoemulsions. Int.J.Ph.Sci. 2011; 3(3):1443-1449.
Kumar A, Sharma S., Kamble R. Self Emulsifying Drug Delivery System (Sedds): Future Aspects. Int J Pharm Pharm Sci. 2010; 2(4):7-13. Hitendra and Sagar / Indian Journal of Novel Drug Delivery 8(3), Jul-Sep, 2016, 123-132 130.
Nazzal S., Smalyukh I.I., Lavrentovich O.D., Khan M. A. Preparation and in vitro characterization of a eutectic based Semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. International Journal of Pharmaceutics. 2012; 235:247-265. DOI: https://doi.org/10.1016/S0378-5173(02)00003-0
Chouksey R., Jain A.K., Pandey H., Maithil A. Development and Bioavailability Studies of Atorvastatin Nanoemulsion. Int. J. Of Pharm. and Life Sci. (IJPLS). 2011; 2(8):982-988.
Gadhave A.D. Nanoemulsions: Formation, Stability and Applications. International Journal for Research in Science and Advanced Technologies. 2014; 2(3):038- 043.
Jincy J., Krishnakumar K., Anish J., Dineshkumar B., Nano-Emulsion in Pharmaceuticals: A Review. Current Research in Drug Targeting, 2015; 5(1):1-4.
Bali V., Ali M., Ali J. Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe. Colloids and Surfaces B: Biointerfaces. 2010; 76:410- 420. DOI: https://doi.org/10.1016/j.colsurfb.2009.11.021
Rui Liu, Yuanyuan Lu, Wanfen Pu, Kunlin Lian, Lin Sun, Daijun Du, Yuyang Song, James J. Sheng. Low-Energy Emulsification of Oil-in-Water Emulsions with Self-Regulating Mobility via a Nanoparticle Surfactant. Industrial & Engineering Chemistry Research 2020, 59 (41) , 18396-18411. DOI: https://doi.org/10.1021/acs.iecr.0c03153
Kunal Kadiya, Supratim Ghosh. Conversion of Viscous Oil-in-Water Nanoemulsions to Viscoelastic Gels upon Removal of Excess Ionic Emulsifier. Langmuir 2019, 35 (52) , 17061-17074. DOI: https://doi.org/10.1021/acs.langmuir.9b02558
Parth Rajeshkumar Bhut, Nilanjan Pal, Ajay Mandal. Characterization of Hydrophobically Modified Polyacrylamide in Mixed Polymer-Gemini Surfactant Systems for Enhanced Oil Recovery Application. ACS Omega 2019, 4 (23) , 20164-20177. DOI: https://doi.org/10.1021/acsomega.9b02279
Stefania Betancur, Lady J. Giraldo, Francisco Carrasco-Marín, Masoud Riazi, Eduardo J. Manrique, Henderson Quintero, Hugo A. García, Camilo A. Franco-Ariza, Farid B. Cortés. Importance of the Nanofluid Preparation for Ultra-Low Interfacial Tension in Enhanced Oil Recovery Based on Surfactant–Nanoparticle–Brine System Interaction. ACS Omega 2019, 4 (14) , 16171-16180. DOI: https://doi.org/10.1021/acsomega.9b02372
Ehsan Nourafkan, Jabbar Gardy, Maryam Asachi, Waqar Ahmed, Dongsheng Wen. Nanoparticle Formation in Stable Microemulsions for Enhanced Oil Recovery Application. Industrial & Engineering Chemistry Research 2019, 58 (28) , 12664-12677. DOI: https://doi.org/10.1021/acs.iecr.9b00760
E. A. El-Sharaky, Amira E. El-Tabey, M. R. Noor El-Din, A. M. Al-Sabagh, M. R Mishrif. Polyoxyethylene Alkenyl Succinate Gemini Emulsifier for Diesel Fuel Nanoemulsions. Energy & Fuels 2019, 33 (6) , 5476-5487. DOI: https://doi.org/10.1021/acs.energyfuels.9b00646
Yousef Kazemzadeh, Mohammad Sharifi, Masoud Riazi. Mutual Effects of Fe3O4/Chitosan Nanocomposite and Different Ions in Water for Stability of Water-in-Oil (w/o) Emulsions at Low–High Salinities. Energy & Fuels 2018, 32 (12) , 12101-12117. DOI: https://doi.org/10.1021/acs.energyfuels.8b02449
ya-Bing Guo, Xiang-An Yue, Joseph Yuchun Fu, Bo Zhang. Relevance between Emulsification Capability and Interfacial Tension of Chemical Flooding Agents. Energy & Fuels 2018, 32 (12) , 12345-12350. DOI: https://doi.org/10.1021/acs.energyfuels.8b03110
Sagheer A. Onaizi, Mohammed Alsulaimani, Mohammed K. Al-Sakkaf, Salem A. Bahadi, Mohamed Mahmoud, Ali Alshami. Crude oil/water nanoemulsions stabilized by biosurfactant: Stability and pH-Switchability. Journal of Petroleum Science and Engineering 2021, 198 , 108173. DOI: https://doi.org/10.1016/j.petrol.2020.108173
Yi Zhao, Fangfang Peng, Yangchuan Ke. Design and characterization of oil-in-water nanoemulsion for enhanced oil recovery stabilized by amphiphilic copolymer, nonionic surfactant, and LAPONITE® RD. RSC Advances 2021, 11 (4) , 1952-1959. DOI: https://doi.org/10.1039/D0RA06080A
Han Zhao, Wanli Kang, Hongbin Yang, Zitong Huang, Bobo Zhou, BauyrzhanSarsenbekuly. Emulsification and stabilization mechanism of crude oil emulsion by surfactant synergistic amphiphilic polymer system. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2021, 609 , 125726. DOI: https://doi.org/10.1016/j.colsurfa.2020.125726
Sole I., Maestro A., Gonzalez C., Solans C., Gutierrez J.M. Optimization of Nanoemulsion Preparation by Low-Energy Methods in an Ionic Surfactant System. Langmuir. 2006; 22(20):8326-8332. DOI: https://doi.org/10.1021/la0613676
Bouchemal K., Briançon S., Perrier E., Fessi H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. International Journal of Pharmaceutics. 2004; 280:241- 251. DOI: https://doi.org/10.1016/j.ijpharm.2004.05.016
Bhosale R.R., Osmani R.A., Ghodake P.P., Shaikh S.M., Chavan S.R. Nanoemulsion: A Review on Novel Profusion in Advanced Drug Delivery. Indian J.Pharm.Biol.Res. 2014; 2(1):122-127. DOI: https://doi.org/10.30750/ijpbr.2.1.19
Shah R.B., Zidan A.S., Funck T., Tawakkul M.A., Nguyenphoa A., Khana M.A. Quality by design: Characterization of self-nanoemulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology. International Journal of Pharmaceutics. 2007; 341:189-194. DOI: https://doi.org/10.1016/j.ijpharm.2007.04.009
Jaiswal M, Dudhe R, Sharma P.K. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015; 5:123- 127. DOI: https://doi.org/10.1007/s13205-014-0214-0
Sun M., Su X., Ding B., He X., Liu X., Yu A., et al., Advances in nanotechnology-based delivery systems for curcumin. Nanomedicine. 2012; 7(7):1085-1100. DOI: https://doi.org/10.2217/nnm.12.80
Rachmawati H., Yee C.W., Rahma A. Formulation of Tablet Containing Curcumin Nanoemulsion. Int J Pharm Sci. 2014; 6(3):115-116.
Vyas T.K., Shahiwala A., Amiji M.M. Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations. International Journal of Pharmaceutics. 2008; 347:93-101. DOI: https://doi.org/10.1016/j.ijpharm.2007.06.016
Hatanaka J., Chikamori H., Sato H., Uchida S., Debari K., Onoue S., et al., Physicochemical and pharmacological characterization of alpha tocopherolloaded nano-emulsion system. International Journal of Pharmaceutics. 2010; 396:188-193. DOI: https://doi.org/10.1016/j.ijpharm.2010.06.017
Patel N.A., Patel N.J. and Patel R.P. Formulation and Evaluation of Curcumin Gel for Topical Application. Pharmaceutical Development and Technology. 2009; 14:83-92. DOI: https://doi.org/10.1080/10837450802409438
MYuKoroleva, E V Yurtov 2012.Nanoemulsions: theproperties, methods of preparation and promisingApplications 81 (1) Russian Academy of SciencesandTurpion Ltd. DOI: https://doi.org/10.1070/RC2012v081n01ABEH004219
Lifshitz IM, Slyozov VV. The kinetics of precipitationfrom supersaturated solid solutions. Journal ofPhysics and Chemistry of Solids 1961; 19:35–50. DOI: https://doi.org/10.1016/0022-3697(61)90054-3
Soheyla H, Foruhe Z. Effect of zeta potential on the properties of nano-drug delivery systems-a review Trop J Pharm Res 2013;12:255-264. DOI: https://doi.org/10.4314/tjpr.v12i2.19
Patil SS, Mohite SK. Development and evaluation of solid dispersion incorporated topical gel of nabumetone. Res J Pharm Tech 2014;716.
Başpınar Y, Gündoğdu E, Köksal C, Karasulu E. Pitavastatin-containing nanoemulsions: Preparation, characterization and in vitro cytotoxicity. J Drug Deliv Sci Technol 2015;29:117-24. DOI: https://doi.org/10.1016/j.jddst.2015.07.003
Teixeira MC, Severino P, Andreani T, Boonme P, Santini A, Silva AM. D-a-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity. Saudi Pharm J 2017;25:231-5. DOI: https://doi.org/10.1016/j.jsps.2016.06.004
Kumar S. Role of Nano-Emulsion in Pharmaceutical Sciences-A Review. Asian Journal of Research in Pharmaceutical Sciences and Biotechnology. 2014; 2(1):1- 15.
Gaikar M.N., Phadtare D.G., Saudagar R.B. A Review on Nanoemulsion Drug Delivery System. International Journal of Institutional Pharmacy and Life Sciences. 2016; 6(3):107-122.
Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S. Nanoemulsions as vehicles for transdermal delivery of aceclofenac. AAPS Pharm Sci Tech 2007;8(4):E104. DOI: https://doi.org/10.1208/pt0804104
Zhu L, Li M, Dong J, Jin Y. Dimethyl silicone dry nanoemulsion inhalations: Formulation study and anti-acute lung injury effect. Int J Pharm 2015;491:292-8. DOI: https://doi.org/10.1016/j.ijpharm.2015.06.041
Hörmann K., Zimmer A. Drug delivery and drug targeting with parenteral lipid nanoemulsions—A review. J. Control. Release. 2016;223:85–98. DOI: https://doi.org/10.1016/j.jconrel.2015.12.016
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Mohit Nagar
This work is licensed under a Creative Commons Attribution 4.0 International License.
